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Study identifier: NCT07222215 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Condition: Estrogen-receptor-positive Breast Cancer · Metastatic Breast Cancer · Breast Cancer  ·  Sponsor: Kristina A. Fanucci

PhasePhase 2
Planned participants297
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this research study is to compare a combination of two drugs, capecitabine and elacestrant to capecitabine alone as a treatment for advanced estrogen receptor-positive (ER+) breast cancer. This study is designed for participants with cancer that has previously stopped responding to medication in the class of therapy called CDK 4/6 inhibitors, including palbociclib, ribociclib, or abemaciclb. The names of the study drugs involved in this study are: * Elacestrant (a type of selective estrogen receptor degrader) * Capecitabine (a type of fluoropyrimidine antimetabolite)

This description comes directly from the study's public registry record.

Talk to the study team

Kristina Fanucci, MD, MHS  ·  617-632-3800  ·  Kristina_Fanucci@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07222215