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Study identifier: NCT07222072 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

Condition: Post Operative Pain · Spinal Surgery  ·  Sponsor: The Cleveland Clinic

PhasePhase 4
Planned participants120
Who can joinAll sexes, 18 Years to 72 Years
Healthy volunteersYes

About this study

The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Stephanie Stoianoff, MBA  ·  12164440231  ·  stoians@ccf.org

Sandra Durbin, CLPN, CCRP  ·  216-269-4073  ·  durbins@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland ClinicCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07222072