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Study identifier: NCT07221851 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders

Condition: Turner Syndrome · Short Stature Homeobox Gene Mutation · Idiopathic Short Stature  ·  Sponsor: Ascendis Pharma A/S

PhasePhase 3
Planned participants186
Who can joinAll sexes, 2 Years to 17 Years
Healthy volunteersNo

About this study

This basket trial will enroll prepubertal children and adolescents with clinically diagnosed and genetically confirmed (if applicable) TS, SHOX-D, SGA, or ISS between ages of ≥2 and \<18 years with open growth plates. The purpose of the study is to see how well treatment with once-weekly lonapegsomatropin works compared to treatment with daily somatropin. Approximately 186 participants will be distributed equally (1:1), to receive either lonapegsomatropin for 2 years or somatropin for 1 year followed by lonapegsomatropin for 1 year. This trial will be conducted in the United States, France, Germany, Italy, Romania, Spain and South Korea.

This description comes directly from the study's public registry record.

Talk to the study team

Ascendis Registry Inquiries  ·  +4561161658  ·  asnd_registryinquiries@ascendispharma.com

Always discuss trial participation with your own doctor first.

Locations (34)

Ascendis Pharma Investigational SitePalo Alto, California, United StatesRecruiting
Ascendis Pharma Investigational SiteSacramento, California, United StatesRecruiting
Ascendis Pharma Investigational SiteAurora, Colorado, United StatesRecruiting
Ascendis Pharma Investigational SiteCentennial, Colorado, United StatesRecruiting
Ascendis Pharma Investigational SiteOrlando, Florida, United StatesRecruiting
Ascendis Pharma Investigational SiteSt. Petersburg, Florida, United StatesRecruiting
Ascendis Pharma Investigational SiteAtlanta, Georgia, United StatesRecruiting
Ascendis Pharma Investigational SiteIdaho Falls, Idaho, United StatesRecruiting
Ascendis Pharma Investigational SiteNew Orleans, Louisiana, United StatesRecruiting
Ascendis Pharma Investigational SiteMinneapolis, Minnesota, United StatesRecruiting
Ascendis Pharma Investigational SiteSaint Paul, Minnesota, United StatesRecruiting
Ascendis Pharma Investigational SiteLake Success, New York, United StatesRecruiting

+ 22 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07221851