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Study identifier: NCT07221500 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

Condition: Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Lymphoma (SLL)  ·  Sponsor: Nurix Therapeutics, Inc.

PhasePhase 2
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a study for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have previously received treatment with a BTK inhibitor (covalent and non-covalent) and a BCL-2 inhibitor. The main purpose of this study is to test if NX-5948 (bexobrutideg) works to treat patients with CLL/SLL. Participation could last up to 5 years, and possibly longer, if the disease does not progress.

This description comes directly from the study's public registry record.

Talk to the study team

Additional Site Contact Information  ·  415-417-3418  ·  clinicaltrials@nurixtx.com

Always discuss trial participation with your own doctor first.

Locations (32)

City of HopeDuarte, California, United StatesRecruiting
Colorado Blood InstituteDenver, Colorado, United StatesRecruiting
University of MiamiCoral Gables, Florida, United StatesRecruiting
Florida Cancer SpecialistsSarasota, Florida, United StatesRecruiting
Fort Wayne Oncology and HematologyFort Wayne, Indiana, United StatesRecruiting
Hematology Oncology of IndianaIndianapolis, Indiana, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
Maryland Oncology HematologySilver Spring, Maryland, United StatesRecruiting
Karmanos Cancer CenterDetroit, Michigan, United StatesRecruiting
Duke UniversityDurham, North Carolina, United StatesRecruiting
Novant Health Cancer InstituteWinston-Salem, North Carolina, United StatesRecruiting
University of CincinnatiCincinnati, Ohio, United StatesRecruiting

+ 20 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07221500