Condition: Squamous Non-small Cell Lung Cancer · Sponsor: Merck Sharp & Dohme LLC
Researchers want to know if intismeran autogene (the study treatment) given with pembrolizumab and chemotherapy can treat metastatic treatment-naive squamous non-small cell lung cancer (NSCLC). Intismeran autogene is designed to help a person's immune system attack their specific cancer. The goal of this study is to learn if people who receive intismeran autogene with pembrolizumab and chemotherapy live longer overall and without the cancer growing or spreading compared to people who receive placebo with pembrolizumab and chemotherapy. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of the study treatment.
This description comes directly from the study's public registry record.
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| Moffitt Cancer Center ( Site 0021) | Tampa, Florida, United States | Recruiting |
| Washington University School of Medicine ( Site 0024) | St Louis, Missouri, United States | Recruiting |
| Valley Health Systems - Ridgewood Campus ( Site 0010) | Paramus, New Jersey, United States | Recruiting |
| New York Oncology Hematology (NYOH) - Albany Medical Center ( Site 9001) | Albany, New York, United States | Recruiting |
| Cleveland Clinic - Ohio ( Site 0016) | Cleveland, Ohio, United States | Recruiting |
| Good Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0025) | Corvallis, Oregon, United States | Recruiting |
| Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 9000) | Nashville, Tennessee, United States | Recruiting |
| Texas Oncology - Central/South Texas ( Site 8002) | Austin, Texas, United States | Recruiting |
| Virginia Cancer Specialists ( Site 0003) | Fairfax, Virginia, United States | Recruiting |
| Swedish Medical Center-Swedish Cancer Institute ( Site 0023) | Seattle, Washington, United States | Recruiting |
| Hospital Italiano de Buenos Aires ( Site 0200) | Ciudad Autonoma de Buenos Aires., Buenos Aires, Argentina | Recruiting |
| Instituto Alexander Fleming ( Site 0201) | Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | Recruiting |
+ 42 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07221474