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Study identifier: NCT07221214 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

Condition: HIV · Alcohol · Smoking Cigarette  ·  Sponsor: Vanderbilt University Medical Center

PhasePhase 2
Planned participants200
Who can joinAll sexes, 18 Years to 89 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if the drug semaglutide works to reduce alcohol intake among adults living with HIV. The main questions it aims to answer are: 1. Does semaglutide lower the average number of alcoholic beverages participants drink per week? 2. Does semaglutide lower the average number of cigarettes participants smoke per day? 3. Does semaglutide decrease the risk for cardiovascular disease among people living with HIV who drink alcohol and/or smoke tobacco? Researchers will compare the effects of semaglutide to a placebo (a look-alike substance that contains no drug) to see if semaglutide works to lower the alcohol intake among participants each week. Participants will: 1. Take semaglutide for 3 months 2. Visit the research clinic 3 times for checkups and tests 3. Provide blood samples, stool samples, and saliva samples for tests.

This description comes directly from the study's public registry record.

Talk to the study team

Hilary A Tindle, MD, MPH  ·  615-875-9726  ·  hilary.tindle@vumc.org

Rachel Jones, MS  ·  615-421-3508  ·  rachel.l.jones3@vumc.org

Always discuss trial participation with your own doctor first.

Locations (1)

Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07221214