Condition: T-cell Acute Lymphoblastic Lymphoma · T-non-Hodgkin Lymphoma · T-cell Acute Lymphoblastic Leukemia · Sponsor: Baylor College of Medicine
Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. This study combines two different ways of fighting disease with antibodies and T cells. Antibodies are types of proteins that protect the body from bacterial and other diseases. T cells, or T lymphocytes, are special infection-fighting blood cells that can kill other cells including tumor cells. Both antibodies and T cells have been used to treat cancer; they have shown promise, but have not been strong enough to cure most patients. T cells can kill tumor cells but there normally are not enough of them to kill all the tumor cells. Some researchers have taken T cells from a person's blood, grown more of them in the laboratory and then given them back to the person. The antibody used in this study is called anti-CD7. This antibody sticks to T-cell leukemia or lymphoma cells because of a substance on the outside of these cells called CD7. CD7 antibodies have been used to treat people with T-cell leukemia and lymphoma. For this study, anti-CD7 has been changed so that instead of floating free in the blood it is now joined to the T cells. When an antibody is joined to a T cell in this way it is called a chimeric receptor. In the laboratory, investigators have also found that T cells work better if they also add proteins that stimulate T cells, such as one called CD28. Adding the CD28 makes the cells…
This description comes directly from the study's public registry record.
Rayne Rouce · 832-824-4716 · rhrouce@txch.org
LaQuisa Hill, MD · 832-824-4670 · LaQuisa.Hill@bcm.edu
Always discuss trial participation with your own doctor first.
| Houston Methodist Hospital | Houston, Texas, United States | Not Yet Recruiting |
| Texas Children's Hospital | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07220993