Condition: Carrier of Phenylketonuria · Healthy · Sponsor: University of Missouri-Columbia
The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygous carriers of phenylketonuria (PKU). The main questions it aims to answer are: * Do PKU carriers experience prolonged elevations in brain Phe levels following oral ingestion of dietary Phe? * Do PKU carriers experience disruptions in cognitive functioning following oral ingestion of dietary Phe? * Do PKU carriers experience atypical brain activity following oral ingestion of dietary Phe? Researchers will compare PKU carriers and non-carriers following oral ingestion of dietary Phe and a placebo. Participants will: * Consume Phe or a placebo at two separate visits to our facility * At each visit, they will complete a series of MRIs and cognitive tests throughout the day
This description comes directly from the study's public registry record.
Shawn Christ · 573-884-8140 · christse@missouri.edu
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| University of Missouri-Columbia | Columbia, Missouri, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07220265