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Study identifier: NCT07219576 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Retifanlimab and Ruxolitinib In Solid Malignancies

Condition: Non Small Cell Lung Carcinoma · Renal Cell Carcinoma  ·  Sponsor: University of California, San Diego

PhasePhase 1/Phase 2
Planned participants40
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn what dose of ruxolitinib can be given safely together with retifanlimab in patients with metastatic renal cell carcinoma and non-small cell lung carcinoma. The main question it aims to answer is: What is the maximum dose of ruxolitinib that can be used safely in patients with metastatic renal cell carcinoma and non-small cell lung carcinoma, and will it work? Participants will: Take drug ruxolitinib twice a day and keep a diary of when they take ruxolitinib at home; visit the clinic for infusions of retifanlimab every 4 weeks; visit the clinic for checkups and tests.

This description comes directly from the study's public registry record.

Talk to the study team

Rana McKay, MD  ·  (858) 822-5354  ·  cancerCTO@health.ucsd.edu

Alexandrea Cronin  ·  (858) 822-5354  ·  cancerCTO@health.ucsd.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of California, San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07219576