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Study identifier: NCT07218926 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

Condition: Gastrointestinal Neoplasms  ·  Sponsor: GlaxoSmithKline

PhasePhase 3
Planned participants450
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out if a new drug, called IDRX-42 (also known as GSK6042981), is effective in treating adults with a type of cancer called Gastrointestinal Stromal Tumors (GIST) when compared to another drug named sunitinib. The study will see if IDRX-42 works well and is safe for participants whose GIST has spread or cannot be surgically removed, and who have already taken the drug imatinib. Participants whose disease worsens after receiving sunitinib in this study may cross over to receive GSK6042981, at investigator's discretion and if additional eligibility criteria are met.

This description comes directly from the study's public registry record.

Talk to the study team

US GSK Clinical Trials Call Center  ·  877-379-3718  ·  GSKClinicalSupportHD@gsk.com

EU GSK Clinical Trials Call Center  ·  +44 (0) 20 89904466  ·  GSKClinicalSupportHD@gsk.com

Always discuss trial participation with your own doctor first.

Locations (124)

GSK Investigational SitePhoenix, Arizona, United StatesRecruiting
GSK Investigational SiteLa Jolla, California, United StatesRecruiting
GSK Investigational SiteLos Angeles, California, United StatesRecruiting
GSK Investigational SiteSan Francisco, California, United StatesRecruiting
GSK Investigational SiteNew Haven, Connecticut, United StatesRecruiting
GSK Investigational SiteJacksonville, Florida, United StatesRecruiting
GSK Investigational SiteMiami, Florida, United StatesRecruiting
GSK Investigational SiteOrlando, Florida, United StatesRecruiting
GSK Investigational SiteTampa, Florida, United StatesRecruiting
GSK Investigational SiteIowa City, Iowa, United StatesRecruiting
GSK Investigational SiteOverland Park, Kansas, United StatesRecruiting
GSK Investigational SiteBoston, Massachusetts, United StatesRecruiting

+ 112 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07218926