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Study identifier: NCT07218341 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Condition: Chronic Lymphocytic Leukemia · Lymphoma, Small Lymphocytic  ·  Sponsor: Eli Lilly and Company

PhasePhase 4
Planned participants150
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the long-term safety of pirtobrutinib in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is open to those who completed J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038) for continued access to the study intervention or continued follow-up visits. Treatment will be given every 4 weeks and this study is expected to last about 5 years.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (50)

Mitchell Cancer InstituteMobile, Alabama, United StatesRecruiting
Arizona Oncology Associates, P.C. - HOPETucson, Arizona, United StatesNot Yet Recruiting
Cancer Specialists, LLCJacksonville, Florida, United StatesRecruiting
Minnesota Oncology Hematology, P.A.Coon Rapids, Minnesota, United StatesNot Yet Recruiting
Cayuga Cancer CenterIthaca, New York, United StatesNot Yet Recruiting
Memorial Sloan-Kettering Cancer Center (MSKCC) - New YorkNew York, New York, United StatesRecruiting
Oncology Hematology Care IncCincinnati, Ohio, United StatesNot Yet Recruiting
Texas Oncology - ParisFort Worth, Texas, United StatesNot Yet Recruiting
US Oncology - Texas OncologyKyle, Texas, United StatesNot Yet Recruiting
The Alfred HospitalMelbourne, AustraliaNot Yet Recruiting
LKH - Universitätsklinikum der PMU SalzburgSalzburg, AustriaNot Yet Recruiting
AZ DeltaRoeselare, BelgiumNot Yet Recruiting

+ 38 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07218341