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Study identifier: NCT07217171 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

Condition: Bladder Cancer · Squamous Cell Carcinoma of the Lung · Esophageal Squamous Cell Carcinoma  ·  Sponsor: EvolveImmune United, Inc

PhasePhase 1
Planned participants160
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have been ineligible for treatment with these medications. Participants with advanced or metastatic cancer who meet all eligibility criteria may be eligible to participate in the study.

This description comes directly from the study's public registry record.

Talk to the study team

Evolve Study Team  ·  12032086584  ·  Evolve104Study@evolveimmune.com

Always discuss trial participation with your own doctor first.

Locations (12)

City of HopeDuarte, California, United StatesRecruiting
USC/Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Yale University Cancer CenterNew Haven, Connecticut, United StatesRecruiting
The Winship Cancer Institute Emory UniversityAtlanta, Georgia, United StatesRecruiting
START MidwestGrand Rapids, Michigan, United StatesRecruiting
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Thomas Jefferson University, Sidney Kimmel Cancer CenterPhiladelphia, Pennsylvania, United StatesRecruiting
SCRINashville, Tennessee, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Virginia Cancer SpecialistsFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07217171