● Recruiting

Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Condition: Leukemia, Myeloid, Acute · Myelodysplastic Syndromes · Mixed Phenotype Acute Leukemia · Sponsor: Orca Biosystems, Inc.

PhasePhase 2

Planned participants80

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

This study will evaluate the safety, tolerability, and efficacy of Orca-T in participants undergoing reduced intensity or non-myeloablative allogeneic hematopoietic cell transplantation (alloHCT) for hematologic malignancies. Orca-T is an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a specific, unique donor. It is composed of purified hematopoietic stem and progenitor cells (HSPCs), purified regulatory T cells (Tregs), and conventional T cells (Tcons).

This description comes directly from the study's public registry record.

Talk to the study team

Chief Medical Officer · 650-246-9601 · info@orcabio.com

Medical Director · 650-246-9601 · info@orcabio.com

Always discuss trial participation with your own doctor first.

Locations (6)

UCLA Department of Medicine	Los Angeles, California, United States	Recruiting
Moffitt Cancer Center	Tampa, Florida, United States	Recruiting
John Theurer Cancer Center at Hackensack University Medical Center	Hackensack, New Jersey, United States	Recruiting
Weill Cornell Medicine - New York Presbyterian Hospital	New York, New York, United States	Recruiting
Oregon Health and Science University	Portland, Oregon, United States	Recruiting
Vanderbilt University, Ingram Cancer Center	Nashville, Tennessee, United States	Recruiting

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Source record: clinicaltrials.gov/study/NCT07216443