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Study identifier: NCT07215234 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Condition: Geographic Atrophy  ·  Sponsor: Sanofi

PhasePhase 1/Phase 2
Planned participants104
Who can joinAll sexes, 60 Years to no upper limit
Healthy volunteersNo

About this study

This is a sequential Phase 1/2, two-part, multicenter study on safety, tolerability, and efficacy of one-time intravitreal SAR446597 for the treatment of participants with Geographic Atrophy (GA) secondary to Age-related Macular Degeneration (AMD). The core phase duration will be approximately 2 years for each participant. An Extended Follow-Up (EFU) phase of 3 years follows the core phase. The treatment is a one-time intravitreal injection of SAR446597 (or sham as applicable in Part II).

This description comes directly from the study's public registry record.

Talk to the study team

Trial Transparency email recommended (Toll free for US & Canada)  ·  800-633-1610  ·  contact-us@sanofi.com

Always discuss trial participation with your own doctor first.

Locations (18)

Associated Retina Consultants - Peoria- Site Number : 8400011Peoria, Arizona, United StatesRecruiting
Retina Macula Institute of Arizona- Site Number : 8400028Scottsdale, Arizona, United StatesRecruiting
Vitreo Retinal Associates - Gainesville- Site Number : 8400004Gainesville, Florida, United StatesRecruiting
Retina Vitreous Associates of Florida - St. Petersburg- Site Number : 8400002St. Petersburg, Florida, United StatesRecruiting
University Retina - Lemont- Site Number : 8400005Lemont, Illinois, United StatesRecruiting
The Retina Group of Washington - Chevy Chase- Site Number : 8400009Chevy Chase, Maryland, United StatesRecruiting
Cumberland Valley Retina Consultants - Hagerstown- Site Number : 8400003Hagerstown, Maryland, United StatesRecruiting
Oregon Retina- Site Number : 8400017Eugene, Oregon, United StatesRecruiting
Mid Atlantic Retina - Bethlehem- Site Number : 8400031Bethlehem, Pennsylvania, United StatesRecruiting
Retina Consultants of Austin- Site Number : 8400015Austin, Texas, United StatesRecruiting
Austin Clinical Research - Austin - Anderson Mill Road- Site Number : 8400007Austin, Texas, United StatesRecruiting
Retina Consultants of Texas - Bellaire- Site Number : 8400019Bellaire, Texas, United StatesRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07215234