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Study identifier: NCT07213778 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

Condition: Symptomatic Venous Thromboembolism (VTE)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants2000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (32)

Horizon Clinical ResearchLa Mesa, California, United StatesRecruiting
Eisenhower Medical CenterRancho Mirage, California, United StatesRecruiting
Sky Ridge Medical CenterLone Tree, Colorado, United StatesRecruiting
South Florida Joint Replacement CenterDeerfield Beach, Florida, United StatesRecruiting
Medical Research of Westchester - MPLUS Research NetworkMiami, Florida, United StatesRecruiting
Phoenix Clinical ResearchTamarac, Florida, United StatesRecruiting
Endeavor HealthSkokie, Illinois, United StatesRecruiting
The Orthopaedic Research Foundation, Inc.Indianapolis, Indiana, United StatesRecruiting
NextStage Clinical Research, St. Francis Medical ParkWichita, Kansas, United StatesRecruiting
Velocity Clinical Research, AnnapolisAnnapolis, Maryland, United StatesRecruiting
Sinai Hospital of Baltimore, Inc.Baltimore, Maryland, United StatesRecruiting
Tufts Medical CenterBoston, Massachusetts, United StatesRecruiting

+ 20 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07213778