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Study identifier: NCT07213570 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer

Condition: Colorectal Cancer Metastatic  ·  Sponsor: National Cancer Institute, Naples

PhasePhase 2
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The investigators hypothesize that patients with mCRC RAS-mutant eligible for a second line treatment with good prognostic features, identified as single metastatic site, long progression free survival (PFS) in first line treatment, might benefit from a personalized approach, with less intensive treatment with regorafenib as part of a continuum-of-care strategy aimed at ensuring quality of life and extending survival.

This description comes directly from the study's public registry record.

Talk to the study team

Antonio Avallone, MD  ·  003908117770357  ·  a.avallone@istitutotumori.na.it

Always discuss trial participation with your own doctor first.

Locations (1)

Istituto Nazionale Tumori | "Fondazione Pascale"Naples, Italy, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07213570