Condition: Relapsed Neuroblastoma · Refractory Neuroblastoma · Relapsed Osteosarcoma · Sponsor: Baylor College of Medicine
The purpose of this study is to find the largest safe dose of i15.NKG2D.zeta-NK cells in combination with C7R.GD2.CAR-T cells, and additionally to evaluate how long they can be detected in patients' blood and what affect they have on patients' cancer. Patients eligible for this study have neuroblastoma or osteosarcoma that expresses a substance on the cancer cells called GD2. This cancer has either come back after treatment or did not respond to the standard or other investigational treatments or therapies used to treat it. There is no standard treatment for these types of advanced cancers at this time. This is a gene transfer research study using special immune cells called NK cells and T cells. NK cells and T cells are types of white blood cell that help the body fight infection. The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different ways of fighting cancer: NK cells and T cells. T cells are special infection-fighting blood cells that can kill cells infected with viruses and tumor cells. NK cells, another kind of infection-fighting cell, can recognize a wide range of cells in distress, including tumor cells and cells that help protect tumor cells in the cancer environment. Both NK cells and T cells have been used individually to treat patients with cancers. They have shown promise, but have not been strong enough individually to cure most patients. Investigators have foun…
This description comes directly from the study's public registry record.
Robin Parihar, MD, PhD · 832-824-4746 · rxpariha@texaschildrens.org
Martha Arredondo · 832-824-1201 · Martha.Arredondo@bcm.edu
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| Texas Children's Hospital | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07211737