Condition: Infection · Sepsis · Sponsor: Semmelweis University
The study aims to compare the efficacy and safety of an absolute procalcitonin (PCT) value-guided antibiotic initiation protocol and a protocol using the kinetics of PCT (the difference between the actual and the previous day value) in hemodynamically stable critically ill patients with suspected new-onset infection on admission or during ICU stay. The main question it aims to answer: * Can the investigators decrease the number of unnecessary AB therapies using the kinetics of PCT insted of using absolute PCT values? * Is it safe to use PCT kinetics together with the clinical picture to guide AB initiation? AB therapy will be initiated according to predefined PCT protocols (Kinetics and Absolute Group). After 72 hours of treatment, an independent multidisciplinary team (infectologist, microbiologist and intensivist) will decide about the necessity of the treatment with all the relevant results in hand.
This description comes directly from the study's public registry record.
Márton Papp · +36206663224 · papp.marton@semmelweis.hu
Zsolt Molnár · +36303026668 · molnar.zsolt1@semmelweis.hu
Always discuss trial participation with your own doctor first.
| Saint Margaret's Hospital | Budapest, Hungary | Not Yet Recruiting |
| Semmelweis University, Department of Intensive Therapy | Budapest, Hungary | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07211620