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Study identifier: NCT07210632 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

Condition: Brain Cancer · HGG · Glioma  ·  Sponsor: Eben Rosenthal

PhaseEARLY_Phase 1
Planned participants38
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

High-grade gliomas (HGGs) are among the most aggressive and treatment-resistant brain tumors. Immunotherapy with checkpoint inhibitors like nivolumab has shown promise, but its efficacy remains variable and poorly understood in this patient population. This clinical trial investigates a novel imaging-enabled formulation of nivolumab-IRDye800 (nivo800) which incorporates a near-infrared (NIR) fluorescent dye to enable real-time visualization of drug distribution within tumor tissue.

This description comes directly from the study's public registry record.

Talk to the study team

Nicole Jones  ·  615-936-2807  ·  nicole.l.jones@vumc.org

Makenna Brown  ·  (615)421-4370  ·  makenna.l.brown@vumc.org

Always discuss trial participation with your own doctor first.

Locations (1)

Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07210632