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Study identifier: NCT07210086 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

Condition: Prostate Cancer  ·  Sponsor: City of Hope Medical Center

PhasePhase 2
Planned participants50
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study aims to evaluate the role of PSMA-PET and circulating tumor DNA (ctDNA) in monitoring prostate cancer progression and response to radiotherapy (RT). Specifically, it investigates how often early progression is detected on PSMA-PET before PSA rise, examines PET responses of lesions treated with RT at 6 and 12 months and their correlation with PSA changes and later progression, examines ctDNA changes following ablative-intent RT to metastatic sites, and explores the relationship between PSMA-PET radiological findings and ctDNA dynamics.

This description comes directly from the study's public registry record.

Talk to the study team

Rose Li, MD, PhD  ·  6263598111  ·  yunroseli@coh.org

Always discuss trial participation with your own doctor first.

Locations (1)

City of Hope Medical CenterDuarte, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07210086