Condition: Post-craniotomy · Pain · Sponsor: Beijing Tiantan Hospital
Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain. As FA is highly lipophilic by merging into emulsified lipid microspheres, it has a high affinity to the surgical incision and inflammatory tissues to achieve targeted drug therapy and prolonged duration of action. On base of the previous report that local NSAIDs achieved therapeutic tissue concentrations despite a plasma concentration of \<5% of that of systemic administration, a low-dose of FA might be considered a preferential option for local infiltration to avoid anti-platelet related side effects, such as intra-cerebral bleeding. In this study, the investigators attempt to evaluate the clinical effects of pre-emptive scalp infiltration with low-dose FA and ropivacaine for postoperative analgesia after craniotomy.
This description comes directly from the study's public registry record.
Fang Luo, MD · +86 5997 6660 · 13611326978@163.com
Wei Zhang, MD · +86 5997 6660 · 13810045210@163.com
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| Beijing Tiantan Hospital | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07209345