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Study identifier: NCT07209306 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

WHO Psychological Interventions for Mental Health Outcomes in Migrants Resettled in Italy: the ADVANCE Trial

Condition: Distress, Psychological · Distress, Emotional  ·  Sponsor: Universita di Verona

PhaseNA
Planned participants237
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Rationale: Migrant populations face numerous mental health risk factors, including unmet expectations, inadequate support, acculturation challenges, and legal hurdles. These stressors hinder their lives during and after migration. The World Health Organization has developed scalable psychological interventions, including Self Help Plus (SH+) and its online version Doing What Matters in Times of Stress (DWM), which are designed for delivery by non-professional helpers and adaptable to various cultures and mental health issues. While initial randomized controlled trials (RCTs) show these interventions are effective, their medium to long-term efficacy, implementability and scalability have not been thoroughly evaluated. Objectives: This study aims to examine the efficacy of SH+ and DWM versus a psychological placebo in reducing anxiety and depression symptoms among migrants experiencing elevated psychological distress. Additionally, it seeks to collect implementation outcomes to assess the feasibility and potential for scaling up these interventions. Study design: We will conduct a hybrid three-arm efficacy-implementation randomized controlled trial. Study population Adult asylum seekers, refugees or migrants with self-reported elevated psychological distress (K10 \>15.9) (n=237). Intervention : All participants (in the three comparison groups) will receive Psychological First Aid (PFA) and enhanced care as usual (ECAU). In addition to PFA and ECAU, the intervention group 1 …

This description comes directly from the study's public registry record.

Talk to the study team

Marianna Purgato, PhD, Associate professor  ·  +390458124884  ·  marianna.purgato@univr.it

Corrado Barbui, MD, Full professor  ·  corrado.barbui@univr.it

Always discuss trial participation with your own doctor first.

Locations (1)

WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.Verona, Italy, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07209306