Condition: Head and Neck Cancer · Squamous Cell Carcinoma · Oral Cavity Cancer · Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
The NeoScorch HN study is a single institution multisite phase II trial including 3 cohorts of 25 patients each for patients with newly diagnosed locoregionally advanced, histologically confirmed, head and neck cancer eligible for curative-intent treatment, who will receive neo-adjuvant chemoimmunotherapy-based treatment as well as standard of care adjuvant treatment. The three cohorts include three different aspects of surgical de-escalation in head and neck cancer. The first cohort includes human papillomavirus independent (HPV-) squamous cell carcinoma of the head and neck. The second cohort includes HPV-associated head and neck cancer with radiographic evidence of extranodal extension in neck lymphadenopathy. The third cohort specifically includes malignancies of the sinonasal cavity and skull base which have a propensity for invasion of the orbit, skull base, and maxilla. Surgical treatment of all three of these cohorts has significant morbidity including swallowing, speech, and vision among others.
This description comes directly from the study's public registry record.
Zubair Khan, MBBS, MPH · 4109553157 · ototrials@live.johnshopkins.edu
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| Johns Hopkins Hospital East Baltimore | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07209189