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Study identifier: NCT07209111 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

Condition: Neoplasm Malignant  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants150
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers want to learn if calderasib given alone or with cetuximab can treat certain advanced solid tumors in people with the KRAS G12C mutation. The goals of this study are to learn: * How many people have the cancer respond (get smaller or go away) to calderasib alone or with cetuximab and how these responses compare * About the safety of calderasib alone or with cetuximab and if people tolerate the treatments.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (64)

Greater Baltimore Medical Center ( Site 1104)Baltimore, Maryland, United StatesRecruiting
START Midwest ( Site 1103)Grand Rapids, Michigan, United StatesRecruiting
Comprehensive Cancer Centers of Nevada ( Site 1109)Las Vegas, Nevada, United StatesRecruiting
Rutgers Cancer Institute of New Jersey ( Site 1100)New Brunswick, New Jersey, United StatesRecruiting
START Mountain Region ( Site 1106)West Valley City, Utah, United StatesRecruiting
Virginia Cancer Specialists ( Site 1102)Fairfax, Virginia, United StatesRecruiting
Prince of Wales Hospital-Medical Oncology ( Site 1003)Randwick, New South Wales, AustraliaRecruiting
Westmead Hospital ( Site 1000)Westmead, New South Wales, AustraliaRecruiting
Epworth Freemasons ( Site 1004)Melbourne, Victoria, AustraliaRecruiting
Jewish General Hospital-CRU ( Site 2900)Montreal, Quebec, CanadaRecruiting
FALP ( Site 1200)Santiago, Region M. de Santiago, ChileRecruiting
Centro de Oncología de Precisión ( Site 1202)Santiago, Region M. de Santiago, ChileRecruiting

+ 52 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07209111