Condition: Aging · Visual Perception · Noninvasive Brain Stimulation · Sponsor: Boston University Charles River Campus
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.
This description comes directly from the study's public registry record.
Robert Reinhart, PhD · (617) 353-9481 · rmgr@bu.edu
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Source record: clinicaltrials.gov/study/NCT07208318