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Study identifier: NCT07208058 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS])

Condition: Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis  ·  Sponsor: TJ Biopharma Co., Ltd.

PhasePhase 3
Planned participants30
Who can joinAll sexes, 16 Years to 80 Years
Healthy volunteersNo

About this study

A study designed to evaluate the efficacy, safety, immunogenicity, PK, and PD characteristics of Plonmarlimab in patients with relapsed/refractory rheumatic and immunologic disease-associated MAS, and to explore biomarkers related to the efficacy of Plonmarlimab.

This description comes directly from the study's public registry record.

Talk to the study team

Biwei Zeng  ·  86 13540060494  ·  biwei.zeng@tjbio.com

Always discuss trial participation with your own doctor first.

Locations (18)

Beijing Friendship Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaRecruiting
Peking Union Medical College Hospital, Chinese Academy of Medical SciencesBeijing, Beijing Municipality, ChinaRecruiting
Peking University People's HospitalBeijing, Beijing Municipality, ChinaNot Yet Recruiting
Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, ChinaRecruiting
The Second Affiliated Hospital of Guangxi Medical UniversityNanning, Guangxi, ChinaNot Yet Recruiting
The Second Hospital of Hebei Medical UniversityShijiazhuang, Hebei, ChinaRecruiting
Henan Children's Hospital Zhengzhou Children's HospitalZhengzhou, Henan, ChinaRecruiting
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaRecruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting
The First Affiliated Hospital of Nanchang UniversityNanchang, Jiangxi, ChinaRecruiting
The First Affiliated Hospital of China Medical UniversityShenyang, Liaoning, ChinaWithdrawn
Children's Hospital of Fudan UniversityShanghai, Shanghai Municipality, ChinaRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07208058