Condition: Hypertrophic Cardiomyopathy (HCM) · Sponsor: Rennes University Hospital
Hypertrophic cardiomyopathy (HCM) is a common (\> 1/500 in the general adult population) genetically transmitted disease impacting markedly patients' lives from the early ages to the latest. The phenotype as the prognosis of HCM may greatly differ from one patient to another: most patients present no or few symptoms and a near-normal lifespan, while others are severely symptomatic. Paroxysmal, persistent or permanent atrial fibrillation (AF) is frequent in HCM, occurring in more than 20%-25% of patients and is often considered as an important turning point for the quality of life of these patients. AF decreases cardiac output and exercise tolerance, increases hospitalization rate, and markedly increase the risk of embolic stroke with the need for life-anticoagulation. It has been shown that stroke may precede AF discovery and that it may occur at young ages with devastation consequences. AF also may trigger sudden cardiac death. Observational studies have been conducted to search for parameters which correlate with the risk of AF (P wave duration and supra-ventricular burst on the Holter-ECG monitoring, L-wave morphology, degree of hypertrophy, clinical parameters-comorbidities, and size of the left atrium) with no real impact on clinical management. Left Atrial strain (LA-strain) has been recently demonstrated relevant (for instance our pilot work (for predicting stroke and/or AF (a cut-off of 15% is highly specific, 20% being the optimal cut-off). LA-strain (cut-off 20%) c…
This description comes directly from the study's public registry record.
Courpron Julie · 02 99 28 25 55 · dri@chu-rennes.fr
ganivet anne · anne.ganivet@chu-rennes.fr
Always discuss trial participation with your own doctor first.
| CHU Angers | Angers, France | Not Yet Recruiting |
| CHU Bordeaux Haut-Levêque | Bordeaux, France | Not Yet Recruiting |
| CHU Brest - Hôpital La Cavale Blanche | Brest, France | Not Yet Recruiting |
| CHU Caen | Caen, France | Not Yet Recruiting |
| CHU Dijon - Hôpital François Mitterrand | Dijon, France | Recruiting |
| CHU Grenoble Alpes | Grenoble, France | Not Yet Recruiting |
| CHU Lille | Lille, France | Not Yet Recruiting |
| APHM - Hôpital La Timone | Marseille, France | Not Yet Recruiting |
| CHU de Nantes -Hôpital Nord Laennec | Nantes, France | Not Yet Recruiting |
| AP-HP Höpital la Pitié-Salpétrière | Paris, France | Not Yet Recruiting |
| APHP Hopital Européen Georges Pompidou | Paris, France | Not Yet Recruiting |
| APHP, Hôpital Lariboisière | Paris, France | Not Yet Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07202897