Condition: Multiple Sclerosis · Neuromyelitis Optica Spectrum Disorders · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) · Sponsor: Assistance Publique Hopitaux De Marseille
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging. It leverages advanced multiparametric brain and spinal cord imaging at high (3T) and ultra-high magnetic fields (7T) to assess structural, functional, metabolic, and mesoscale changes in the central nervous system (CNS). Particular emphasis is placed on sodium (23Na-MRI) and phosphorus (31P-MRI) imaging, along with layer-dependent brain connectivity analysis. The primary objective is to evaluate the impact of neuronal energy failure, measured via sodium concentration, on functional and structural reorganization in both healthy individuals and patients with various neurological conditions. Directed brain network models will be constructed from MRI data to quantify the connectivity strength (in- and out-degree) of cortical nodes. These connectivity metrics will be correlated with sodium concentrations to assess energy failure and its role in network reorganization. Longitudinal follow-up over two years is planned for subgroups with clinically progressive diseases. Secondary objectives include decoding metabolic, microstructural, and functional signatures of successful aging at the laminar level; characterizing disease-specific patterns of cortical and spinal microstructure associated with physical and cognitive dysfunction; describing longitudinal mesoscale and metabolic changes; and generating r…
This description comes directly from the study's public registry record.
Jan-Patrick STELLMANN · +33 (0) 4 91 38 48 07 · jan-patrick.stellmann@ap-hm.fr
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| Chu Timone | Marseille, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07202494