Condition: Breast Cancer Prevention · Sponsor: Harokopio University
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors. Traditional prevention strategies have shown limited effectiveness, creating the need for innovative approaches. The MELIORA project develops an AI-driven digital tool, the Virtual Coach (VC), to promote sustainable behaviour change in physical activity, diet, and alcohol use. Three randomized-controlled studies will be conducted: MELIORA-HEALTHY (women at risk, n=1080 in Greece, Lithuania, Spain), MELIORA-PATIENTS (women undergoing treatment, n=400 in Lithuania, Spain), and MELIORA-SURVIVORS (post-treatment survivors, n=600 in Lithuania, Spain, Sweden). Participants across diverse regions and backgrounds will be randomized to standard lifestyle advice or the same advice plus the MELIORA VC app. Each study lasts 12 months, with outcomes assessed at baseline, 6, and 12 months. The primary outcome is physical activity, with secondary outcomes including sedentary behaviour, diet, alcohol use, and quality of life. If effective, the MELIORA VC could offer a scalable, cost-effective model for BC prevention and survivorship care, providing valuable evidence to guide public health strategies.
This description comes directly from the study's public registry record.
Yannis Manios, Professor · +30 2109549156 · manios@hua.gr
Always discuss trial participation with your own doctor first.
| Harokopio University | Athens, Greece | Recruiting |
| Lietuvos Sveikatos Mokslų Universitetas (Lsmu) | Kaunas, Lithuania | Recruiting |
| Pagalbos Onkologiniams Ligoniams Asociacija (Pola L T) | Kaunas, Lithuania | Recruiting |
| Fundación Para El Fomento de La Investigación Sanitaria Y Biomédica de La Comunitat Valenciana (Fisabio) | Valencia, Spain | Recruiting |
| INCLIVA - Instituto de Investigación Sanitaria | Valencia, Spain | Recruiting |
| Bröstcancerföreningen Amazona I Stockholms Län (Amazona) | Stockholm, Sweden | Recruiting |
| Karolinska Institutet | Stockholm, Sweden | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07200427