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Study identifier: NCT07199517 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Condition: Cigarette Smoking · Tobacco Use · Cigarette Smoking Behavior  ·  Sponsor: Abramson Cancer Center at Penn Medicine

PhaseNA
Planned participants472
Who can joinAll sexes, 21 Years to no upper limit
Healthy volunteersYes

About this study

This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national sample of people unmotivated to quit smoking. Participants will be randomized 2:1 to choose one of two harm-reduction products (ECIG, ONP) versus a medicinal nicotine control condition (nicotine patch + lozenge, NPL), receive a 4-week starter product regimen, and then be followed for 6 months to assess use behavior.

This description comes directly from the study's public registry record.

Talk to the study team

Janet Audrain-McGovern, Ph.D.  ·  215-746-7145  ·  audrain@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07199517