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Study identifier: NCT07198724 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

Condition: Metastatic Breast Cancer · HER2 Low Breast Carcinoma · HER2-negative Breast Cancer  ·  Sponsor: Kristina A. Fanucci

PhasePhase 1/Phase 2
Planned participants65
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to evaluate the safety and efficacy of elacestrant in combination with trastuzumab deruxtecan (T-DXd) in participants with hormone receptor-positive (HR+), HER2-low or HER2-ultralow, metastatic breast cancer that is resistant to prior CDK4/6 inhibitor and endocrine therapy. The names of the study drugs involved in this study are: * Elacestrant (a type of selective estrogen receptor degrader) * Trastuzumab deruxtecan (a type of standard of care antibody drug conjugate)

This description comes directly from the study's public registry record.

Talk to the study team

Kristina Fanucci, MD  ·  617-362-3800  ·  Kristina_Fanucci@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07198724