Condition: Transthyretin (TTR) Amyloid Cardiomyopathy · Sponsor: University of Texas Southwestern Medical Center
The objective of this study is to determine the association of clinically prescribed, on-label, TTR stabilizing therapy (e.g. tafamidis or acoramidis) with levels of circulating transthyretin amyloid aggregates (TAAs, a surrogate for amyloid disease activity) measured serially over time in patients with transthyretin cardiac amyloidosis (ATTR-CA). To accomplish this objective, the hypothesis that TTR stabilizing therapy will be associated lower circulating TAAs over time will be tested. Completion of this study will advance the understanding of the influence of ATTR-CA treatments on circulating evidence of amyloidosis and justify the role of blood testing to monitor treatment response in patients with ATTR-CA.
This description comes directly from the study's public registry record.
Jerah Sanchez · 214-645-7303 · jerahmarie.sanchez@utsouthwestern.edu
Amy Browning · Amy.Browning@utsouthwestern.edu
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| UT Southwestern Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07196839