Condition: First Episode Psychosis (FEP) · Psychosis · Sponsor: University of Nottingham
The project aims to explore changes in brain chemistry in individuals who have recently experienced psychosis. Recent research suggests that chemicals in the brain, specifically one called glutamate, may behave differently in people who have experienced psychosis compared to those who have not. It is also known that some individuals with psychosis can find tasks involving memory and attention more challenging. This study aims at understanding how brain chemistry is linked to memory and attention, and if this is different between people who have and have not experienced psychosis. The study will also investigate how a commonly used brain stimulation technique might help people with psychosis and other conditions by altering brain chemistry for a very short period. Non-invasive brain stimulation using very weak electrical stimulation has been used to help improve symptoms in individuals with psychosis and many other conditions, and has been shown to alter brain chemistry for a few hours after stimulation. However, it does not work for everyone. It will be investigated if levels of glutamate can predict whether brain stimulation will help an individual or not. In other words, the study investigates if glutamate can be used as a marker for tailoring treatments. This project also aims to collect personal experiences or challenges that individuals with psychosis face. This information will be gathered through interviews. This will help to understand what specific difficulties ind…
This description comes directly from the study's public registry record.
Claudia Danielmeier, PhD · +44 115 84 66360 · claudia.danielmeier@nottingham.ac.uk
Mohammad Z U H Katshu, PhD · +44 1158231287 · mohammad.katshu@nottingham.ac.uk
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| University of Nottingham | Nottingham, Nottinghamshire, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07196423