Condition: Obstructive Sleep Apnea · Down Syndrome (Trisomy 21) · Sponsor: Hospices Civils de Lyon
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals. In children, OSA can have long-term consequences on the development and on the cardiovascular system. Down Syndrome (DS) is a genetic disorder associated with intellectual disability and many comorbidities. The prevalence of OSA is particularly high in patients with DS, from infancy. In a recent study by Fauroux et al. (2024), OSA was diagnosed in 97% infants and early diagnosis and intervention from the age of 6 months was associated with better neurocognitive outcome at 3 years old. However, polysomnography (PSG - the gold standard method for diagnosing OSA) is poorly accessible, highlighting the need to develop new strategies to prevent and to screen OSA early in infancy. OSA can be linked to some orofacial abnormalities presented by patients with DS. Indeed, orofacial functions and structures ca play a crucial role in OSA. For example, nose breathing allows the tongue to act as a stimulator of the transverse maxillary growth during childhood, allowing the upper airway to develop properly. The primary objective of the present study is to explore the relationships between oro-myo-facial functions, more specifically non-nutritive sucking, and the severity of OSA in 6 months old infants with DS. The main hypothesis is that OSA severity (estimated by the obstructive apnea hypopn…
This description comes directly from the study's public registry record.
Patricia PF FRACO, MD, PhD · +33 4 27 85 60 52 · patricia.franco@chu-lyon.fr
Aurore GUYON, PHD · +33 4 27 85 52 47 · aurore.guyon@chu-lyon.fr
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| Service d'épileptologie clinique, des troubles du sommeil et de neurologie fonctionnelle de l'enfant | Bron, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07195253