Condition: Hormon Receptor Positive Breast Cancer · Breast Cancer · Sponsor: MedSIR
This trial will study a type of breast cancer defined by the expression of hormone receptor in the cancer cells (HR+). Patients will be treated with ribociclib, a cyclin-dependent kinase inhibitor, and camizestrant, a selective estrogen receptor degrader (SERD) and complete ER antagonist. The main purpose of the Study is to analyze the efficacy (to find out how effective a treatment is) of ribociclib in combination with camizestrant in patients with advanced HR+ breast cancer who have received endocrine therapy (ET) in early breast cancer setting for at least 5 years, of which at least 2 years with aromatase inhibitor (AI). Ribociclib plus camizestrant efficacy will be determined by assessing the period from treatment initiation until disease progression, defined as progression free survival (PFS). The anticipated favorable clinical benefits of the combination of ribociclib and camizestrant therapy are projected to outweigh the risks of this treatment. This Study will be performed in full compliance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and all applicable local Good Clinical Practice (GCP) and regulations.
This description comes directly from the study's public registry record.
MEDSIR · + 34 932 214 135 · contact.trials@medsir.org
Always discuss trial participation with your own doctor first.
| Städtisches Klinikum Dessau | Dessau, Germany | Active Not Recruiting |
| Hospital General Universitario Dr. Balmis | Alicante, Spain | Active Not Recruiting |
| Hospital Clínic Barcelona | Barcelona, Spain | Recruiting |
| Hospital Dexeus | Barcelona, Spain | Recruiting |
| Institut Català d'Oncologia Girona - ICO Girona | Girona, Spain | Recruiting |
| HU Virgen de las Nieves | Granada, Spain | Active Not Recruiting |
| Hospital Universitario de Jerez de la Frontera | Jerez de la Frontera, Spain | Recruiting |
| Hospital Universitario de León | León, Spain | Recruiting |
| Beata Maria Ana | Madrid, Spain | Active Not Recruiting |
| Hospital Ramón y Cajal | Madrid, Spain | Active Not Recruiting |
| Hospital Regional Universitario de Málaga | Málaga, Spain | Active Not Recruiting |
| Sant Joan de Reus | Reus, Spain | Recruiting |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07195227