Condition: Metastatic Ewing Sarcoma · Sponsor: H. Lee Moffitt Cancer Center and Research Institute
This single arm study is designed to demonstrate the feasibility of a radically different approach for an exceptionally high-risk subset of MES with widely metastatic disease (WMES). We incorporate the use of evolutionary principles that apply to species and population dynamics as related to adaptation and extinction to populations of cancer cells that similarly adapt and that we are attempting to make extinct, resulting in a cure for the patient. Such principles include an initial intense first strike to deplete the bulk of the cancer cells, followed by a series of sequential second strikes towards eliminating residual, resistant populations, followed by a prolonged period of maintenance chemotherapy to eliminate any remnant cells, using agents generally regarded to be active against newly diagnosed ES.
This description comes directly from the study's public registry record.
Jessica Crimella · 813-745-6250 · Jessica.Crimella@moffitt.org
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham (Children's of Alabama) | Birmingham, Alabama, United States | Recruiting |
| Phoenix Children's Hospital | Phoenix, Arizona, United States | Recruiting |
| Connecticut Children's Medical Center | Hartford, Connecticut, United States | Not Yet Recruiting |
| University of Florida | Gainesville, Florida, United States | Recruiting |
| Nemours Jacksonville | Jacksonville, Florida, United States | Not Yet Recruiting |
| University of Miami | Miami, Florida, United States | Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States | Recruiting |
| University of Kentucky | Lexington, Kentucky, United States | Not Yet Recruiting |
| Helen DeVos Children's Hospital | Grand Rapids, Michigan, United States | Not Yet Recruiting |
| Roswell Park Comprehensive Cancer Center | Buffalo, New York, United States | Not Yet Recruiting |
| Montefiore Medical Center | The Bronx, New York, United States | Recruiting |
| University of North Carolina | Chapel Hill, North Carolina, United States | Not Yet Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07194044