Condition: Prematurity; Extreme · Prematurity; Decision Support · Necrotising Enterocolitis · Sponsor: Imperial College London
PREM-IMPACT is a UK-based observational study exploring how caring for a very premature baby-particularly one affected by necrotising enterocolitis (NEC)-impacts families over the first year after hospital discharge. NEC is a serious bowel disease that can occur in premature babies, often requiring surgery and prolonged hospitalisation. This study runs alongside the WHEAT International Trial, which investigates whether pausing or continuing milk feeds during blood transfusions affects the risk of NEC in very preterm babies. PREM-IMPACT acts as a nested economic evaluation of the WHEAT Trial, helping to understand whether different feeding practices around transfusion offer good value for money from both the NHS and family perspective. PREM-IMPACT will collect detailed data on babies' health-related quality of life, as well as the financial, emotional, and social impact on parents and siblings. Families are recruited from neonatal units when their baby is ready to go home and complete questionnaires at three timepoints: 1) just before discharge, 2) six months later, and 3) twelve months later. Questionnaires cover health, wellbeing, healthcare use, and costs to the family (such as travel, time off work, or extra care needs). A dedicated research nurse based at the lead NHS site helps coordinate follow-up centrally. By studying families of babies with and without NEC, this project aims to clarify the burden of prematurity and NEC on infant outcomes and family wellbeing. The …
This description comes directly from the study's public registry record.
Joe Montebello, MSc · +442075947271 · j.montebello@imperial.ac.uk
Always discuss trial participation with your own doctor first.
| Norfolk and Norwich University Hospital | Norwich, Norfolk, United Kingdom | Recruiting |
| University Hospital Coventry | Coventry, United Kingdom | Recruiting |
| Liverpool Women's Hospital | Liverpool, United Kingdom | Recruiting |
| Chelsea & Westminster Hospital | London, United Kingdom | Recruiting |
| Imperial College Healthcare NHS Trust (St Mary's Hospital, Paddington) | London, United Kingdom | Recruiting |
| John Radcliffe Hospital | Oxford, United Kingdom | Recruiting |
| Queen Alexandra Hospital | Portsmouth, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07192393