Condition: Cognitive Impairment Associated With Schizophrenia (CIAS) · Sponsor: Kynexis B.V.
This is a Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) effects of 3 different dose regiments of KYN-5356 and placebo for 28 days. Participants will be randomized to one of 4 treatment groups: placebo, KYN-5356 low dose, KYN-5356 medium dose, KYN-5356 high dose. Participants will be admitted to the clinic on Day -3 and will remain in residence at the clinic for 32 days, from baseline through the treatment period. Participants will be administered investigational medicinal product on Days 1 through 28. Efficacy, safety, PK and exploratory PD assessments will be performed throughout the dosing period. Participants will be discharged on Day 29 after safety assessments are completed and return for a follow-up visit on Day 42. A subset of participants from selected sites will undergo electrophysiological assessments to evaluate the effect of KYN-5356 on neurophysiological measures of brain function.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Woodland International Research Group | Little Rock, Arkansas, United States | Recruiting |
| Synapse Clinical Trials | Cerritos, California, United States | Recruiting |
| Synergy Research Center | Lemon Grove, California, United States | Recruiting |
| Cenexel CNS | Los Alamitos, California, United States | Recruiting |
| NeuroBehavioral Hospitals of the Palm Beaches - South | Boynton Beach, Florida, United States | Recruiting |
| Cenexel RCA | Hollywood, Florida, United States | Recruiting |
| Segal Trials | Miami Lakes, Florida, United States | Terminated |
| Cenexel ACMR | Atlanta, Georgia, United States | Recruiting |
| Cenexel iResearch Atlanta | Decatur, Georgia, United States | Recruiting |
| Uptown Research Institute | Chicago, Illinois, United States | Recruiting |
| Cenexel CBH | Gaithersburg, Maryland, United States | Recruiting |
| Arch Clinical Trials | St Louis, Missouri, United States | Recruiting |
+ 3 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07191483