Condition: Acute Hypoxemic Respiratory Failure · Sponsor: University Hospital, Angers
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress. The primary objectives of invasive mechanical ventilation are to reduce respiratory effort and improve oxygenation. However, this intervention is also associated with both direct and indirect adverse effects, mainly linked to the need for sedation and often neuromuscular blockade. These include hemodynamic compromise, neuromuscular weakness, ventilator-induced lung injury, and infectious complications. An ideal intubation strategy would therefore strike a balance: avoiding the risks of delayed intubation-such as refractory hypoxemia, excessive respiratory effort, and patient self-inflicted lung injury (P-SILI)-while limiting complications associated with invasive mechanical ventilation by withholding it in patients who might otherwise recover without. To date, the optimal strategy for achieving this risk-benefit balance remains uncertain. Clinical practice suggests a broad consensus on the necessity of intubation when so-called safety criteria are met: severe hypoxemia (SaO₂/FiO₂ ratio \< 88), marked respiratory distress (use of accessory muscles, thoracoabdominal paradox, respiratory rate \> 40/min), extra-respiratory manifestations of hypoxia (e.g., altered consciousness), and/or uncontrolled hemodynamic instability. Beyond these safety thresholds, however, de…
This description comes directly from the study's public registry record.
Mathilde TAILLANTOU-CANDAU, Doctor · +33 (0)2 41 35 58 65 · Mathilde.Taillantou-candau@chu-angers.fr
Matthieu Le Lay · +33 (0)2 41 35 58 91 · DRCI-Promotion-Interne@chu-angers.fr
Always discuss trial participation with your own doctor first.
| Angers University Hospital, ICU | Angers, France | Recruiting |
| Le Mans Hospital, ICU | Le Mans, France | Not Yet Recruiting |
| Nantes University Hospital, ICU | Nantes, France | Not Yet Recruiting |
| Orléans University hospital, ICU | Orléans, France | Not Yet Recruiting |
| Pitié-Salpétrière Hospital, Paris University Hospital, ICU | Paris, France | Not Yet Recruiting |
| Guadeloupe University Hospital, ICU | Pointe à Pitre, France | Not Yet Recruiting |
| Rennes University Hospital, ICU | Rennes, France | Not Yet Recruiting |
| Tours University Hospital, ICU | Tours, France | Not Yet Recruiting |
| Vannes Hospital, ICU | Vannes, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07189078