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Study identifier: NCT07188896 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC)

Condition: Advanced Renal Cell Carcinoma (aRCC) · Metastatic Renal Cell Carcinoma ( mRCC) · Clear Cell Renal Cell Carcinoma (ccRCC)  ·  Sponsor: Brian Rini

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This three-arm randomized phase 2 trial will enroll advanced clear cell RCC patients (all IMDC risk groups). Patients will be randomized 2:2:1 to either Arm A (fianlimab/ cemiplimab/ ipilimumab), Arm B (fianlimab/ cemiplimab), or Arm C (standard ipilimumab/ nivolumab), respectively.

This description comes directly from the study's public registry record.

Talk to the study team

Brian Rini, MD  ·  615-936-8422  ·  brian.rini@vumc.org

Allison Lipps  ·  317-634-5842  ·  alipps@hoosiercancer.org

Always discuss trial participation with your own doctor first.

Locations (2)

Vanderbilt-Ingram Cancer CenterNashville, Tennessee, United StatesRecruiting
Froedtert and The Medical College of WisconsinMilwaukee, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07188896