Condition: Surgical Site Infection After Major Surgery · Anaesthesia · Major Complications · Sponsor: Monash University
Our specific aims are to investigate whether conservative (≤30%), intermediate (50%), or liberal (80%) inspired oxygen during and immediately after surgery: Aim 1: Reduces surgical site infections (SSIs or "wound infections") and other healthcare-associated infections (pneumonia and sepsis). Aim 2: Reduces a pooled composite of serious postoperative complications, leading to a faster and more complete recovery after surgery, and thus increases "days alive and at home up to 30 days after surgery" (DAH30). Primary hypothesis: Liberal (80%) oxygen concentration delivered with anesthesia in patients undergoing major surgery reduces the incidence of SSIs after surgery compared to conservative (≤30%) or intermediate (50%) oxygen concentration. Secondary hypothesis: Hyperoxia (50-80%) delivered with anesthesia in patients undergoing major surgery increases the incidence of pulmonary and other complications after surgery compared to conservative (≤30%) oxygen concentration, resulting in fewer Days At Home (DAH). PROMPT enrolls patients undergoing elective or semi-elective surgery.
This description comes directly from the study's public registry record.
Paul S Myles, DSc · +6190762000 · p.myles@alfred.org.au
Trisha Peel, PhD · +61 3 9076 5436 · trisha.peel@monash.edu
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| The Alfred | Melbourne, Victoria, Australia | Recruiting |
| Wellington Hospital | Wellington, NZ, New Zealand | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07186634