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Study identifier: NCT07184996 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

Condition: Ulcerative Colitis  ·  Sponsor: Sanofi

PhasePhase 3
Planned participants980
Who can joinAll sexes, 16 Years to 80 Years
Healthy volunteersNo

About this study

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis (UC). Study details include: The study duration may be up to 35 weeks with: * Screening period * 12-week Sub-Study 1 (Single-Arm Open-Label Feeder Induction) or Sub-Study 2 (Pivotal Induction) * 12-week Sub-Study 3 (Extended Induction for non-responders) * 45 days follow-up visit for participants who do not enroll into the maintenance study (EFC18359) The treatment duration will be up to 12 weeks in each sub-study. The number of scheduled on-site visits will be up to 8 for the Sub-Study 1 and Sub Study 2 or a maximum of 15 visits for participants completing extended induction.

This description comes directly from the study's public registry record.

Talk to the study team

Trial Transparency email recommended (Toll free for US & Canada)  ·  800-633-1610  ·  contact-us@sanofi.com

Always discuss trial participation with your own doctor first.

Locations (191)

Onyx Clinical Research - Site Number: 8400021Peoria, Arizona, United StatesRecruiting
One of a Kind Clinical Research Center LLC - Site Number: 8400061Scottsdale, Arizona, United StatesRecruiting
Del Sol Research Management, LLC - Site Number: 8400012Tucson, Arizona, United StatesRecruiting
Preferred Research Partners - Site Number: 8400018Little Rock, Arkansas, United StatesRecruiting
FOMAT - Unio Specialty Care Arcadia - Site Number: 8400027Arcadia, California, United StatesRecruiting
Alliance Research Institute - Site Number: 8400008Canoga Park, California, United StatesRecruiting
Southern California GI & Liver Centers - Site Number: 8400062Coronado, California, United StatesRecruiting
GMC Clinical Research, LLC - Site Number: 8400113Folsom, California, United StatesRecruiting
TLC Clinical Research Inc. - Site Number: 8400030Los Angeles, California, United StatesRecruiting
United Medical Doctors CA - Site Number: 8400044Murrieta, California, United StatesRecruiting
Medical Associates Research Group - Site Number: 8400063San Diego, California, United StatesRecruiting
Santa Maria Gastroenterology - FOMAT Medical Research HyperCORE - Site Number: 8400025Santa Maria, California, United StatesRecruiting

+ 179 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07184996