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Study identifier: NCT07183592 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial

Condition: Intensive Care (ICU) · Central Venous Catheter Related Infections · Critical Care Nursing  ·  Sponsor: University Hospital, Angers

PhaseNA
Planned participants2830
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In the intensive care unit, patients' care and secure drugs administration require a central venous catheter. These invasive devices can lead to complications, particularly infections. Most preventive recommendations focus on catheter insertion, line handling, and dressings. Few recommendations adress catheter dwell time, which is certainly the main source of infection. Part of the prevention strategy is the regular and systematic replacement of infusion sets , as they may become contaminated during use, mainly through the hands of healthcare professionals. Prolonged use increases the risk of infection. Infusion lines changes involve disconnecting the old sets, discarding infusion devices containing drug residues, and replacing them with new sterile devices. Current international guidelines recommend replacing these sets every 4 days, and the Center for Disease Control and Prevention recommends not exceeding 7 days. Replacing these devices requires the time of qualified nurses, numerous sterile medical devices, and medications. In addition to the intended effect on infection prevention, the procedure has impacts on workload and costs. The objective of the study is to demonstrate that changing infusion set every 7 days does not increase the rate of central venous catheters related infections compared with changing infusion set every 4 days.

This description comes directly from the study's public registry record.

Talk to the study team

Carole Haubertin  ·  +332 41 35 40 82  ·  Carole.Haubertin@chu-angers.fr

Aurélie Hautefort  ·  +332 41 35 58 99  ·  aurelie.hautefort@chu-angers.fr

Always discuss trial participation with your own doctor first.

Locations (27)

La Réunion University HospitalSaint-Pierre, La Réunion, FranceNot Yet Recruiting
Albi HospitalAlbi, FranceNot Yet Recruiting
Angers University HospitalAngers, FranceRecruiting
Belfort HospitalBelfort, FranceNot Yet Recruiting
Bourges HospitalBourges, FranceNot Yet Recruiting
Caen University HospitalCaen, FranceNot Yet Recruiting
CH CarcassonneCarcassonne, FranceNot Yet Recruiting
Chartres HospitalChartres, FranceNot Yet Recruiting
Cholet HospitalCholet, FranceNot Yet Recruiting
Colombes HospitalColombes, FranceNot Yet Recruiting
Corbeil-Essonnes HospitalCorbeil-Essonnes, FranceNot Yet Recruiting
AP-HP - Henri Mondor HospitalCréteil, FranceNot Yet Recruiting

+ 15 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07183592