Condition: Magnesium Sulfate · Remifentanil · S 100beta · Sponsor: University General Hospital of Patras
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.
This description comes directly from the study's public registry record.
Sotiria Rizopoulou, M.D.,M.Sc. · +306949454352 · rizsotiria@gmail.com
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| University General Hospital of Patras | Pátrai, Achaia, Greece | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07181564