Condition: NSCLC · Adjuvant Drug Therapy · EGFR · Sponsor: Betta Pharmaceuticals Co., Ltd.
Non-small cell lung cancer (NSCLC) accounts for over 85% of lung cancers. Approximately 30-40% of East Asian adenocarcinoma patients harbor EGFR mutations. Third-generation EGFR-TKIs achieve a median PFS of about 20 months as first-line therapy, but resistance eventually develops. Studies like MARIPOSA-2 confirm that amivantamab combined with chemotherapy ± lazertinib or immunotherapy regimens (ivucitinib/sintilimab + bevacizumab + chemotherapy) can extend median PFS post-resistance from approximately 4 months to 6-8 months. As a third-generation TKI, befitinib has demonstrated PFS of 16-22 months in both first-line and post-T790M mutation settings. This study aims to further evaluate the feasibility and safety of "pemetrexed + carboplatin followed by befotertinib" for patients resistant to third-generation TKIs.
This description comes directly from the study's public registry record.
Shaodong Hong · 15920527656 · hongshd@sysucc.org.cn
Always discuss trial participation with your own doctor first.
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Recruiting |
| The Cancer Center of The Fifth Affiliated Hospital of Sun Yat-sen University | Zhuhai, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07181499