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Study identifier: NCT07181109 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Condition: High Risk Cardiovascular Disease · Hypertension · High Cardiovascular Risk  ·  Sponsor: Alnylam Pharmaceuticals

PhasePhase 3
Planned participants11000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Information Line  ·  1-877-ALNYLAM  ·  clinicaltrials@alnylam.com

Clinical Trial Information Line  ·  1-877-256-9526  ·  clinicaltrials@alnylam.com

Always discuss trial participation with your own doctor first.

Locations (995)

Clinical Trial SiteBirmingham, Alabama, United StatesRecruiting
Clinical Trial SiteBirmingham, Alabama, United StatesRecruiting
Clinical Trial SiteFairhope, Alabama, United StatesRecruiting
Clinical Trial SiteFoley, Alabama, United StatesRecruiting
Clinical Trial SiteHuntsville, Alabama, United StatesNot Yet Recruiting
Clinical Trial SiteHuntsville, Alabama, United StatesRecruiting
Clinical Trial SiteSheffield, Alabama, United StatesRecruiting
Clinical Trial SiteChandler, Arizona, United StatesRecruiting
Clinical Trial SiteGilbert, Arizona, United StatesRecruiting
Clinical Trial SiteGlendale, Arizona, United StatesNot Yet Recruiting
Clinical Trial SiteMesa, Arizona, United StatesRecruiting
Clinical Trial SitePhoenix, Arizona, United StatesRecruiting

+ 983 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07181109