Condition: Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer · Head &Amp;Amp; Neck Squamous Cell Carcinoma · Larynx Squamous Cell Carcinoma · Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
Delays between surgery and the initiation of post-operative radiotherapy (S-PORT) in head and neck cancer (HNC) patients are prevalent and associated with worse oncologic outcomes. This pilot study evaluates whether a proactive, automated care coordination system (PRONTO-HN) can improve adherence to recommended S-PORT intervals of ≤42 days at the Centre hospitalier de l'Université de Montréal (CHUM). The study is a single-center, quasi-experimental, interrupted time-series design with two phases. Group A (control) includes patients treated before the intervention (using a prospectively maintained database from August 2024 to August 2025). Group B (intervention) includes patients treated with the new coordination system from September 2025 to September 2026. The intervention includes automated alerts, multidisciplinary task coordination, and risk stratification based on a predictive model developed and published by our team. This model uses only pre-operative data to estimate the likelihood that a patient will require adjuvant therapy after surgery, stratifying patients into high- and low-risk categories. High-risk patients receive intensified coordination protocols, including early oncology and dental consultations and shorter target times for pathology results. Primary objective: Reduce the proportion of patients with S-PORT \> 42 days. Secondary/tertiary objectives: Reduce mean S-PORT time. Evaluate impacts on overall, locoregional, and disease-free survival in a 2- and …
This description comes directly from the study's public registry record.
Apostolos Christopoulos, MD, MSc · +1 (514) 625-7360 · a.christopoulos@umontreal.ca
Gabriel S Dayan, MD · 5147782303 · gabriel.dayan@umontreal.ca
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| Centre Hospitalier de l'Université de Montréal | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07180901