Condition: Cerebral Autoregulation · Blood Pressure · Dynamic Cerebral Autoregulation · Sponsor: University of Nottingham
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples
This description comes directly from the study's public registry record.
Harry Keevil, MB BChir · +441332 724676 · harry.keevil@nottingham.ac.uk
Tim England, MBChB PhD · +441332724676 · Timothy.England@nottingham.ac.uk
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| School of Medicine, University of Nottingham, Royal Derby Hospital Centre | Derby, Derbyshire, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07179887