Condition: Muscular Atrophy · Insulin Resistance · Muscle Protein Synthesis · Sponsor: Queen's University
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are: How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest? Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest: * Magnetic resonance imaging of the thigh muscles * Strength testing of the thigh muscles * Insulin sensitivity testing in response to a mixed meal * Exogenous glucose oxidation in response to a mixed meal * Muscle biopsies from the thigh muscles * Blood samples
This description comes directly from the study's public registry record.
Chris McGlory, PhD. · 6135336000 · chris.mcglory@queensu.ca
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| Queen's Univeristy | Kingston, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07178353