Condition: Osteoarthritis of the CMC-1 Joint · Sponsor: Karolinska Institutet
Osteoarthritis in the base of the thumb is one of the most common forms of hand arthritis. It usually appears in middle age, particularly in women, and can cause significant pain and loss of function. Early treatment often includes splints, painkillers, joint protection techniques, or steroid injections. If these measures are not enough, surgery is considered. The current standard operation in Sweden is trapeziectomy-removing the trapezium. This usually gives good pain relief at rest, but many patients continue to experience pain when loading the hand and reduced grip strength. Another surgical option is trapeziometacarpal limited excision (TLE), where only part of the bone is removed to keep the thumb slightly longer, which may improve strength. Both procedures are non-implant surgeries. A newer alternative is total joint arthroplasty (TJA), where the joint is replaced with a prosthesis. Early studies suggest that this may allow for quicker recovery and possibly better strength compared to trapeziectomy. However, it is more expensive and carries higher risks, such as implant loosening or dislocation. So far, research has not proven that it offers better long-term results. The TRACE study (A single arm trial of Thumb base Replacement Arthroplasty for osteoarthritis Compared to External controls) is designed to help answer this question. Instead of randomizing patients, this study will follow a group of people receiving thumb joint replacement and compare them to an existin…
This description comes directly from the study's public registry record.
Maria Wilcke, MD, Associate professor · +4681236022 · maria.wilcke@ki.se
Johanna Von Kieseritzky, MD, PhD · 081236000 · johanna.von.kieseritzky@ki.se
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| Handkirurgiska kliniken Södersjukhuset | Stockholm, Sweden | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07178223